Il n'est pas clair si Modafinil a des contre-indications spГ©cifiques, bien qu'il puisse gГ©nГ©ralement ГЄtre pris avec les mГ©dicaments utilisГ©s pour traiter certains troubles ou conditions physiques. Il est Г©galement utilisГ© hors AMM pour d'autres troubles du sommeil. Certains patients signalent un lГ©ger mal de tГЄte.
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Le modafinil peut ГЄtre un substrat pour les principales enzymes pharmacodynamiques et pharmacocinГ©tiques du cytochrome P450 CYP2D6. La dose initiale recommandГ©e est de 200 mg, et elle doit ГЄtre augmentГ©e Г 400 mg en cas de travail de huit heures. Certaines personnes souffrent de narcolepsie et ne peuvent rien faire pour l'aider, bien qu'elles puissent prendre du modafinil pour dormir un peu mieux.
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